Mix the sauce: In a small bowl, whisk together mayonnaise, sugar-free ketchup, mustard, relish, vinegar, smoked paprika, salt, and pepper. Taste and adjust. Chill while you cook the beef.
Season the beef: In a medium bowl, combine onion powder, garlic powder, smoked paprika, salt, and pepper.
Sprinkle evenly over the ground beef and gently mix. Don’t overwork the meat.
Cook the beef: Heat oil in a large skillet over medium-high. Add beef and break it into crumbles.
Cook 6–8 minutes until browned with little crispy bits.
Add burger flavors: Stir in mustard, Worcestershire, and sugar-free ketchup if using. Let it cook 1–2 minutes more to coat the meat and reduce any liquid.
Prep the veggies: While the beef cooks, chop lettuce, tomatoes, red onion, and pickles. Slice the avocado last to limit browning.
Assemble the bowls: Divide lettuce among 4–6 meal prep containers.
Top with a generous scoop of beef, shredded cheese, tomatoes, onions, and pickles. Add avocado if using.
Drizzle and garnish: Spoon the special sauce over the top or pack it in small containers for later. Sprinkle sesame seeds for a classic burger vibe.
Cool before sealing: Let bowls cool to room temp (about 15–20 minutes) before covering to avoid condensation and soggy lettuce.